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| Keywords: Steven H3N2 Flu ET.jpg Photo Caption The three-dimensional structure of influenza virus from electron tomography The viruses are about 120 nanometers ” about one ten thousandth of a millimeter ” in diameter Source of image and text below http //www niams nih gov/ne/press/2006/12_29 htm NATIONAL INSTITUTES OF HEALTH National Institute of Arthritis and Musculoskeletal and Skin Diseases FOR IMMEDIATE RELEASE Friday December 29 2006 Contact Ray Fleming 301 496-8190 Molecular Anatomy of Influenza Virus Detailed Scientists at the National Institute of Arthritis and Musculoskeletal and Skin Diseases NIAMS part of the National Institutes of Health in Bethesda Md and colleagues at the University of Virginia in Charlottesville have succeeded in imaging in unprecedented detail the virus that causes influenza A team of researchers led by NIAMS' Alasdair Steven Ph D working with a version of the seasonal H3N2 strain of influenza A virus has been able to distinguish five different kinds of influenza virus particles in the same isolate sample and map the distribution of molecules in each of them This breakthrough has the potential to identify particular features of highly virulent strains and to provide insight into how antibodies inactivate the virus and how viruses recognize susceptible cells and enter them in the act of infection Being able to visualize influenza virus particles should boost our efforts to prepare for a possible pandemic flu attack says NIAMS Director Stephen I Katz M D Ph D This work will allow us to ˜know our enemy' much better One of the difficulties that has hampered structural studies of influenza virus is that no two virus particles are the same In this fundamental respect it differs from other viruses; poliovirus for example has a coat that is identical in each virus particle allowing it to be studied by crystallography The research team used electron tomography ET to make its discovery ET is a novel three-dimensional imaging method based on the same principle as the well-known clinical imaging technique called computerized axial tomography but it is performed in an electron microscope on a microminiaturized scale The mission of the National Institute of Arthritis and Musculoskeletal and Skin Diseases NIAMS a part of the Department of Health and Human Services' National Institutes of Health is to support research into the causes treatment and prevention of arthritis and musculoskeletal and skin diseases; the training of basic and clinical scientists to carry out this research; and the dissemination of information on research progress in these diseases For more information about NIAMS call the information Clearinghouse at 301 495-4484 or 877 22-NIAMS free call or visit the NIAMS Web site at www niams nih gov The National Institutes of Health NIH ” The Nation's Medical Research Agency ” includes 27 Institutes and Centers and is a component of the U S Department of Health and Human Services It is the primary federal agency for conducting and supporting basic clinical and translational medical research and it investigates the causes treatments and cures for both common and rare diseases For more information about NIH and its programs visit www nih gov Reference Harris A et al Influenza virus pleiomorphy characterized by cryoelectron tomography PNAS 2006;103 50 19123-19127 PD-USGov Original upload log page en wikisource Steven_H3N2_Flu_ET jpg 2007-01-09 14 16 Ke4roh 400×400× 145847 bytes <nowiki>Photo Caption The three-dimensional structure of influenza virus from electron tomography The viruses are about 120 nanometers ” about one ten thousandth of a millimeter ” in diameter NATIONAL INSTITUTES OF HEALTH National Institute of Arthritis </nowiki> Medicine Pandemic | ||||
