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| Keywords: LDLR pathway.png LDL Receptor Pathway LDL particles blue triangles bind the LDL receptor red on the cell membrane The receptors associate with clathrin green with the adaptor protein adaptin purple and cluster in clathrin-coated pits or caveolae 1 These pinch off as clathrin-coated vesicles 2 As the clathrin dissociates from the vesicle and returns to the cell surface 3 the vesicle fuses with a late endosome 4 The low pH in the late endosome causes the dissociation of the LDL from its receptor which returns to the cell surface via a recycling vesicle 5 The LDL is degraded in the lysosome 6 and its cholesterol is incorporated in the lysosomal membrane while its protein component is hydrolyzed to amino acids that diffuse to the cytoplasm Own 2008-01-10 InfoCan All rights released Endocytosis Lipid metabolism Cluster diagrams | ||||
