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| Keywords: Hemoglobinopathies and the pathogenesis of Plasmodium falciparum malaria - Journal.ppat.1003327.g001.png en General mechanisms by which hemoglobinopathies may attenuate the pathogenesis of falciparum malaria A Restriction of red blood cell RBC invasion or intraerythrocytic growth thereby suppressing parasite densities in vivo; B interference with parasite-derived mediators of pathogenesis including those involved in the binding of parasite-infected RBCs iRBCs to extracellular host receptors; C modulation of innate host defenses to favor protective anti-inflammatory responses over those that drive pathogenic pro-inflammatory responses; D enhancement of adaptive cell-mediated and humoral immune responses that clear iRBCs from the blood 2014-10-20 01 01 02 Taylor SM Cerami C Fairhurst RM 2013 Hemoglobinopathies Slicing the Gordian Knot of Plasmodium falciparum Malaria Pathogenesis PLoS Pathog 9 5 e1003327 doi 10 1371/journal ppat 1003327 Taylor SM Cerami C Fairhurst RM 2013 other versions cc-zero Uploaded with UploadWizard Hemoglobin Falciparum malaria Media from PLOS Pathogens | ||||
