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| Keywords: Amino acid catabolism revised.svg Amino acid catabolism This is a modified version of a diagram created July 2011 by Mikael Häggström and based on information in Lippincott's Illustrated Reviews Biochemistry<ref>Chapter 20 Amino Acid Degradation and Synthesis in cite book Denise R PhD Ferrier Lippincott's Illustrated Reviews Biochemistry Lippincott's Illustrated Reviews Lippincott Williams Wilkins Hagerstwon MD 0-7817-2265-9 </ref> The Lippincott's text and the original diagram contained several discrepancies when compared with 5 other prominent biochemistry textbooks This revised diagram represents consensus information from these 5 texts see References below Specific updates -There is a lack of agreement among textbooks about which amino acids enter at acetoacetate which enter at acetoacetyl CoA and which enter directly at acetyl CoA However the key point is that there are 7 amino acids that enter the TCA at acetyl CoA and the diagram has been revised to reflect this -Threonine was previously listed as glucogenic only but it is both glucogenic and ketogenic enters at acetyl CoA and has been updated accordingly -Tryptophan was listed as both glucogenic and ketogenic yet the old version of the diagram did not have it entering at any glucogenic substrate Diagram has been updated to show it enters at pyruvate -Only Phenylalanine and Tyrosine were listed as entering at Fumarate but Aspartate also does The diagram has been updated accordingly References reflist Garrett R H Grisham C M 2008 Biochemistry 5 ed Brooks Cole See p 805 Gropper S S Smith J L Groff J L 2009 Advanced Nutrition and Human Metabolism 5 ed Belmont CA Wadsworth Publishing Company Inc See p 212 Murray R K Bender D Rodwell V W Botham K M Kennelly P J Weil P A 2009 Harper's Illustrated Biochemistry 28 ed McGraw-Hill Medical See p 505 Nelson D L Cox M M 2009 Lehninger Principles of Biochemistry 5 ed W H Freeman and Company See p 688 Stipanuk M H 2006 Biochemical physiological molecular aspects of human nutrition 2 ed Saunders Elsevier See p 369 Made in Inkscape 2012-04-03 http //commons wikimedia org/wiki/File Amino_acid_catabolism svg Mikael Häggström Amino acid catabolism - versions cc-zero Amino acid metabolism | ||||
